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Multivariate optimization and validation of an analytical methodology by RP-HPLC for the determination of losartan potassium in capsules

✍ Scribed by Rudy Bonfilio; César Ricardo Teixeira Tarley; Gislaine Ribeiro Pereira; Hérida Regina Nunes Salgado; Magali Benjamim de Araújo

Book ID: 116903872
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 324 KB
Volume: 80
Category: Article
ISSN: 0039-9140
DOI: 10.1016/j.talanta.2009.06.060

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## Abstract An optimized microwave‐assisted extraction (MAE) method and an efficient HPLC analysis method were developed for fast extraction and simultaneous determination of oleanolic acid and ursolic acid in the fruit of __Chaenomeles sinensis.__ The open vessel MAE process was optimized by using