✦ LIBER ✦
Multivariate genetic analysis of apo AI concentration and HDL subfractions: Evidence for major locus pleiotropy
✍ Scribed by Dr. J. Blangero; S. Williams-Blangero; M. C. Mahaney
- Book ID
- 102221019
- Publisher
- John Wiley and Sons
- Year
- 1993
- Tongue
- English
- Weight
- 322 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0741-0395
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✦ Synopsis
A major locus influencing apolipoprotein A1 (apo AI) serum levels was detected using data from the Donner Laboratory Family Study. This locus accounts for 46% of the phenotypic variability in apo A1 levels. Multivariate segregation analysis revealed that this major locus also has significant pleiotropic effects on the relative distribution of high density lipoproteins.