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Multivariate experimental design for the photocatalytic degradation of imipramine: Determination of the reaction pathway and identification of intermediate products

โœ Scribed by P. Calza; V.A. Sakkas; A. Villioti; C. Massolino; V. Boti; E. Pelizzetti; T. Albanis


Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
883 KB
Volume
84
Category
Article
ISSN
0926-3373

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The degradation behavior of famotidine (1) was investigated in 25% ammonia solution and in 2 M NaOH. The hydrolysis of the drug in ammonia resulted in separation of [3-[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propionamide (3), an impurity listed in British Pharmacopoeia. The treatment w