Multistep Parallel Synthesis of Quinazoline-2,4-diones by a Fluorous Biphasic Concept without Perfluorinated Solvents

✍ Scribed by Dominik Schwinn; Heiko Glatz; Willi Bannwarth

• Publisher: John Wiley and Sons
• Year: 2003
• Tongue: German
• Weight: 115 KB
• Volume: 86
• Category: Article
• ISSN: 0018-019X
• DOI: 10.1002/hlca.200390010

✦ Synopsis

Abstract

Based on perfluoro‐tagged benzyl alcohol adsorbed via fluorous–fluorous interactions on fluorous reversed‐phase silica gel (FRPSG), we have performed a multistep synthesis leading finally to a small library of quinazoline‐2,4‐diones. The whole reaction sequence runs without isolation of intermediates and most importantly, without the need of perfluorinated solvents.