Dephosphorylation of p-ERK1/2 in relatio
✍
Carolin K. Hausherr; Ilka B. Schiffer; Susanne Gebhard; Andreas Banić; Berno Tan
📂
Article
📅
2006
🏛
John Wiley and Sons
🌐
English
⚖ 250 KB
👁 1 views
## Abstract Several studies have shown that HER‐2/neu (erbB‐2) blocking therapy strategies can cause tumor remission. However, the responsible molecular mechanisms are not yet known. Both ERK1/2 and Akt/PKB are critical for HER‐2‐mediated signal transduction. Therefore, we used a mouse tumor model