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Multipoint linkage analysis of the short arm of chromosome 11 in non-insulin dependent diabetes including maturity onset diabetes of youth

✍ Scribed by S. O'Rahilly; P. Patel; O. J. Lehmann; A. Tybjaerg-Hansen; J. Nerup; R. C. Turner; J. S. Wainscoat

Publisher: Springer
Year: 1992
Tongue: English
Weight: 510 KB
Volume: 89
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00217125

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✦ Synopsis

Members of three families with maturity onset diabetes of youth (MODY) and seven with "common" type 2 diabetes were typed for six DNA markers (H-RAS, INS, HBBC, PTH, CALC1, CAT) on the short arm of chromosome 11. Using conventional pairwise linkage analysis, close linkage in the MODY families was excluded for all six markers. By multipoint analysis and a genetic map of the short arm of chromosome 11, MODY was excluded from a region of at least 35 and up to 60 centiMorgans (cM) on the short arm of chromosome 11. Multipoint analysis in the type 2 families also excludes linkage to the INS, H-RAS region of at least 3 and up to 30 cM. This study using multipoint linkage analysis in non-insulin dependent diabetes provides strong evidence against a role for mutations in or around the insulin gene in the causation of MODY or type 2 diabetes in the families studied.

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