Multiplex high-throughput gene mutation analysis in acute myeloid leukemia
β Scribed by Jennifer Dunlap; Carol Beadling; Andrea Warrick; Tanaya Neff; William H. Fleming; Marc Loriaux; Michael C. Heinrich; Tibor Kovacsovics; Katalin Kelemen; Nicky Leeborg; Ken Gatter; Rita M. Braziel; Richard Press; Christopher L. Corless; Guang Fan
- Book ID
- 119257710
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 754 KB
- Volume
- 43
- Category
- Article
- ISSN
- 1532-8392
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## Abstract Nβras gene activation occurs via single base substitutions in codons 12, 13, and 61. We have developed a rapid screening method, termed allele specific restriction analysis (ASRA), for detection of Nβras mutations at these three critical codons in acute myeloid leukemia (AML). Patient D