Multiple-threshold models for genetic influences on age of onset for Alzheimer disease: Findings in Swedish twins

Multiple threshold model for the onset o

Multiple threshold model for the onset of alzheimer's disease in the NAS-NRC twin panel

✍ Meyer, Joanne M.; Breitner, John C.S. 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 26 KB 👁 2 views

The three common alleles at the APOE locus influence the onset and lifetime risk of typical late-onset Alzheimer's disease (AD). Other loci may also alter risk of late-onset AD. One may assess the relative influence of APOE on the genetic contribution to AD by estimating the proportion of AD heritab