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Multiple small doses of levodopa plus entacapone produce continuous dopaminergic stimulation and reduce dyskinesia induction in MPTP-treated drug-naïve primates

✍ Scribed by Lance A. Smith; Michael J. Jackson; Ghassan Al-Barghouthy; Sarah Rose; Mikko Kuoppamaki; C. Warren Olanow; Peter Jenner

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
35 KB
Volume
20
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

The original article to which this Erratum refers has been published in Movement Disorders 2005;20(3)306–314.

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Multiple small doses of levodopa plus en
Multiple small doses of levodopa plus entacapone produce continuous dopaminergic stimulation and reduce dyskinesia induction in MPTP-treated drug-naïve primates
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## Abstract Long‐acting dopamine agonist drugs induce a lower incidence of dyskinesia in MPTP‐treated primates and patients with Parkinson's disease compared to pulsatile treatment with levodopa, supporting the concept of continuous dopaminergic stimulation as a means of dyskinesia avoidance. We ex

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Effect of pulsatile administration of levodopa on dyskinesia induction in drug-naïve MPTP-treated common marmosets: Effect of dose, frequency of administration, and brain exposure
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## Abstract Levodopa (L‐dopa) consistently primes basal ganglia for the appearance of dyskinesia in parkinsonian patients and 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine hydrochloride (MPTP) ‐treated primates. This finding may reflect its relatively short duration of effects resulting in pulsatile