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Multiple signaling pathways are involved in erythropoietin-independent differentiation of erythroid progenitors in polycythemia vera

✍ Scribed by Valérie Ugo; Christophe Marzac; Irène Teyssandier; Frédéric Larbret; Yann Lécluse; Najet Debili; William Vainchenker; Nicole Casadevall


Book ID
113615713
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
276 KB
Volume
32
Category
Article
ISSN
0301-472X

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Regulation of normal hematopoiesis by neuropeptide substance P (SP) and its amino terminal fragment, SP(1-4), has been reported. Endogenous erythroid colony (EEC) formation without erythropoietin is characteristic of polycythemia vera (PV), a chronic myeloproliferative disorder. We investigated the