Multiple Sclerosis Immunology: A Foundation for Current and Future Treatments

✍ Scribed by Vijay K. Kuchroo, Thomas Korn (auth.), Takashi Yamamura, Bruno Gran (eds.)

• Publisher: Springer-Verlag New York
• Year: 2013
• Tongue: English
• Leaves: 468
• Edition: 1
• Category: Library

✦ Synopsis

The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the “new” MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and—even more—the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that “translation” is real and not just virtual.

✦ Table of Contents

Front Matter....Pages i-xvii
Th17 Cells in Autoimmune Inflammation and Demyelination in the Central Nervous System....Pages 1-25
Regulatory T Cells in MS....Pages 27-47
T-bet: A Critical Regulator of Encephalitogenic T Cells....Pages 49-70
Antigen-Presenting Cells in the Central Nervous System....Pages 71-94
The Role of B Cells in Multiple Sclerosis....Pages 95-114
Diet, Gut Flora, and Multiple Sclerosis: Current Research and Future Perspectives....Pages 115-126
GM-CSF in Autoimmune Inflammation of the Central Nervous System....Pages 127-147
The Role of Toll-Like Receptors in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis....Pages 149-176
Macrophages and Microglia in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis....Pages 177-195
Genetics of Multiple Sclerosis....Pages 197-228
Gene Expression Profiling and Pathway Analysis for Identification of Molecular Targets in MS....Pages 229-255
Systems Biology for the Study of Multiple Sclerosis....Pages 257-268
Checkpoints in the Development of Pathogenic and Regulatory T Cells in Experimental Autoimmune Encephalomyelitis—A Basis for Current and Future Interventions in MS....Pages 269-293
Modeling MS in Nonhuman Primates....Pages 295-314
A Novel Concept of Treatment in MS: Targeting Both Oligodendrocyte Death and Inflammatory Processes by Inhibiting Poly(Adp-Ribose) Polymerase....Pages 315-340
Association of Multiple sclerosis with Other Autoimmune Diseases....Pages 341-356
Current and Future Treatments of Multiple Sclerosis....Pages 357-384
Targeting CD52 for the Treatment of Multiple Sclerosis....Pages 385-399
Haematopoietic Stem Cells for the Treatment of MS....Pages 401-431
Mesenchymal Stem Cells for the Treatment of Multiple Sclerosis....Pages 433-455
Back Matter....Pages 457-461

✦ Subjects

Immunology; Gene Function; Molecular Medicine