✦ LIBER ✦

Multiple sclerosis and viruses

✍ Scribed by Michel Brahic

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 65 KB
Volume: 68
Category: Article
ISSN: 0364-5134
DOI: 10.1002/ana.22057

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✦ Synopsis

Abstract

Discussing the problem of multiple sclerosis and viruses should not be limited to reviewing the epidemiological evidence in favor, or against, a particular candidate, such as Epstein‐Barr virus or human herpes virus 6. In this text, I discuss the difficulty of going from association to causation in human epidemiology; the fact that viruses can trigger or prevent autoimmunity; the problem of our very limited knowledge of the viruses that we harbor as part of our metagenome; and the role of such viral flora in multifactorial diseases and also, possibly, in health. ANN NEUROL 2010;68:6–8

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We appreciate the supportive comments offered by Dr Gold. We agree that his work in an animal model and our work in tissue culture is complementary. In the discussion section of our article, we also speculated whether excess nerve growth factor might be "turning down" the rate of axonal growth. This