Multiple Sclerosis and Related Disorders

✍ Scribed by Douglas S. Goodin (Eds.)

• Publisher: Elsevier
• Year: 2014
• Tongue: English
• Leaves: 693
• Series: Handbook of Clinical Neurology 122
• Edition: 1
• Category: Library

✦ Synopsis

Multiple Sclerosis (MS) is generally understood to be an inflammatory autoimmune disease of the central nervous system.  While we still are not certain of the root cause of MS, research results suggest that unknown environmental factors and the presence of specific genes seem the most probable targets.  MS causes an inflammatory response in the central nervous system leading to neurodegeneration, oligodendrocyte death, axonal damage, and gliosis. Over the past five years ongoing research has greatly expanded our understanding of the pathogenesis of MS, detailed insight into the epidemiology and genetic factors related to MS, the introduction of new technologies and tests to better diagnose and predict the future course of the disease and the introduction of new treatments targeting MS.  This collection of review chapters provides a comprehensive reference into the science and clinical applications of the latest Multiple Sclerosis research and will be a valuable resource for the neuroscience research community and the clinical neurology community of researchers and practitioners.

• A comprehensive tutorial reference detailing our current foundational understanding of Multiple Sclerosis
• Includes chapters on key topics including the genetics of MS, MRI imaging and MS, and the latest treatment options
• Each chapter is translational and focuses on current research and impact on diagnosis and treatment options

✦ Table of Contents

Content:
Series Page Page ii
Copyright Page iv
Available titles Page v
Foreword Page vii Michael J. Aminoff, François Boller, Dick F. Swaab
Preface Pages ix-x Douglas S. Goodin
Contributors Pages xi-xiii
Chapter 1 - Immune regulation of multiple sclerosis Pages 3-14 Hans-Peter Hartung, Orhan Aktas, Til Menge, Bernd C. Kieseier
Chapter 2 - Pathology of multiple sclerosis and related inflammatory demyelinating diseases Pages 15-58 Alexandra Kutzelnigg, Hans Lassmann
Chapter 3 - The good and the bad of neuroinflammation in multiple sclerosis Pages 59-87 Matthias Naegele, Roland Martin
Chapter 4 - Demyelination in multiple sclerosis Pages 89-99 Catherine Lubetzki, Bruno Stankoff
Chapter 5 - Axonal loss in multiple sclerosis: causes and mechanisms Pages 101-113 Gerson Criste, Bruce Trapp, Ranjan Dutta
Chapter 6 - Insights from magnetic resonance imaging Pages 115-149 Massimo Filippi, Arnaud Charil, Marco Rovaris, Martina Absinta, Maria Assunta Rocca
Chapter 7 - Infections and multiple sclerosis Pages 151-171 Arun Venkatesan, Richard T. Johnson
Chapter 8 - The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment Pages 173-189 Andrew P. Robinson, Christopher T. Harp, Avertano Noronha, Stephen D. Miller
Chapter 9 - Multiple sclerosis genetics Pages 193-209 Bruce A.C. Cree
Chapter 10 - Genetics of primary progressive multiple sclerosis Pages 211-230 Bruce A.C. Cree
Chapter 11 - The epidemiology of multiple sclerosis: insights to disease pathogenesis Pages 231-266 Douglas S. Goodin
Chapter 12 - Multiple sclerosis: diagnosis, differential diagnosis, and clinical presentation Pages 269-290 Jeffrey M. Gelfand
Chapter 13 - MRI mimics of multiple sclerosis Pages 291-316 Esther Sánchez Aliaga, Frederik Barkhof
Chapter 14 - Diagnosis of multiple sclerosis Pages 317-342 Tracy M. Deangelis, Aaron Miller
Chapter 15 - The clinical course of multiple sclerosis Pages 343-369 Christian Confavreux, Sandra Vukusic
Chapter 16 - Early prognosis of multiple sclerosis Pages 371-391 Josephine Swanton, Kryshani Fernando, David Miller
Chapter 17 - Clinical outcome measures in multiple sclerosis Pages 393-404 Bernard M.J. Uitdehaag
Chapter 18 - MRI outcomes in the diagnosis and disease course of multiple sclerosis Pages 405-425 Jack H. Simon
Chapter 19 - Multiple sclerosis in children Pages 427-441 Brenda L. Banwell
Chapter 20 - Clinical trials in multiple sclerosis Pages 445-453 Gary Cutter, Ludwig Kappos
Chapter 21 - Glucocorticoid treatment of multiple sclerosis Pages 455-464 Douglas S. Goodin
Chapter 22 - Disease-modifying agents in multiple sclerosis Pages 465-501 Paul W. O’Connor, Jiwon Oh
Chapter 23 - Immunosuppressive treatments in multiple sclerosis Pages 503-511 Darin T. Okuda
Chapter 24 - Symptomatic treatment and management of multiple sclerosis Pages 513-562 Ahmed Toosy, Olga Ciccarelli, Alan Thompson
Chapter 25 - Future treatment approaches to multiple sclerosis Pages 563-577 Joy Derwenskus, Fred D. Lublin
Chapter 26 - Neuromyelitis optica (Devic’s syndrome) Pages 581-599 Dean M. Wingerchuk, Brian G. Weinshenker
Chapter 27 - Acute disseminated encephalomyelitis and other inflammatory demyelinating variants Pages 601-611 Neil Scolding
Chapter 28 - Acute inflammatory myelopathies Pages 613-667 Bruce A.C. Cree
Chapter 29 - Clinical neurophysiology of multiple sclerosis Pages 671-679 Letizia Leocani, Giancarlo Comi
Chapter 30 - Cerebrospinal fluid analysis Pages 681-702 Gavin Giovannoni
Index Pages 703-715

✦ Subjects

Multiple sclerosis;Multiple sclerosis;Treatment;Neurology;Multiple Sclerosis;Central Nervous System Diseases;Neurologie;Nervensystem;Krankheit;Multiple Sklerose;Nervenentzündung;Therapie;Multipel skleros