✦ LIBER ✦

Multiple roles of adrenomedullin revealed by animal models

✍ Scribed by Kathleen M. Caron; Oliver Smithies

Publisher: John Wiley and Sons
Year: 2002
Tongue: English
Weight: 219 KB
Volume: 57
Category: Article
ISSN: 1059-910X
DOI: 10.1002/jemt.10046

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The newly identified adrenomedullin (AM) gene codes for a potent, highly conserved vasodilator that is expressed in many tissues. Many biological functions have been ascribed to AM based on its broad expression pattern and numerous in vitro studies, and it is currently viewed as a multifunctional peptide hormone. Recent advances in gene manipulation have permitted the development of experimental animal systems to help distinguish between gene causes and effects in the context of otherwise normal physiology, and so the normal biological function of the AM gene can be studied within the intact physiological milieu of a whole animal. In this review article, we summarize the recent findings from three different types of genetic experiments involving the AM gene. Microsc. Res. Tech. 57:55–59, 2002. © 2002 Wiley‐Liss, Inc.

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