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Multiple Primary Tumors in the Head and Neckby N. de Vries; J. L. Gluckman


Book ID
125282284
Publisher
Springer Netherlands
Year
1992
Tongue
English
Weight
262 KB
Volume
3
Category
Article
ISSN
0957-5243

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Human leukocyte antigens (HLA) and immunoglobulin (Ig) allotypes were examined in 98 patients with single head and neck cancers, and in 51 patients with multiple primary tumors. Immunoglobulin allotype Km (1) was present in 4% of patients with multiple primary tumors versus 21% in patients with a si

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## Abstract Mutagen sensitivity is a constitutional factor which may be used to identify head‐and‐neck squamous‐cell carcinoma (HNSCC) patients at high risk for the development of multiple primary tumors (MPT). In this retrospective study, mutagen sensitivity was measured in HNSCC patients with a s