Multiple Pituitary Hormone Gradients from Cavernous Sinus Sampling in Patients with Cushing's Disease

1,25-Dihydroxyvitamin D3—mediated transf

1,25-Dihydroxyvitamin D3—mediated transforming growth factor-β release is impaired in cultured osteoblasts from patients with multiple pituitary hormone deficiencies

✍ Jozien G. H. Sterck; Jenneke Klein-Nulend; Elisabeth H. Burger; Paul Lips 📂 Article 📅 2009 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 801 KB

To evaluate the osteoblastic function in patients with multiple pituitary hormone deficiencies (M-PHD) and with isolated growth hormone deficiency (I-GHD), bone cells were cultured and the effects of lo-' M 1,25-dihydroxyvitamin D, (1,25 [OH],D,) on parameters of cell proliferation, osteoblastic dif