Nevoid basal cell carcinoma syndrome (NBCC; Gorlin syndrome), an autosomal dominant disorder linked to 9q22.3-q31, and caused by mutations in PTC, the human homologue of the Drosophila patched gene, comprises multiple basal cell carcinomas, keratocysts of the jaw, palmar/plantar pits, spine and rib
Multiple nevoid basal cell carcinoma syndrome and hodgkin's disease
โ Scribed by Daniel Potaznik; Peter Steinherz
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 283 KB
- Volume
- 53
- Category
- Article
- ISSN
- 0008-543X
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## Abstract Nevoid basal cell carcinoma syndrome (NBCCS) is characterized by developmental defects and tumorigenesis. The clinical manifestations of NBCCS have been reported in large epidemiological studies from the United States, the United Kingdom, and Australia, but not from an Asian country. We
The demonstration that mutations in the Patched (PTCH) gene cause nevoid basal cell carcinoma syndrome (NBCCS) has led to the identification of the exact molecular lesion in a percentage of individuals with the syndrome. In addition, it has been possible to determine, through molecular analysis of p