𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Multiple myeloma with crystalline inclusions in most hemopoietic cells

✍ Scribed by Dr. Laurence Gabriel; Luis Escribano; Jose Perales; Carmen Bellas; Jesus Odriozola; Jose-Luis Navarro

Book ID
102699143
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
655 KB
Volume
18
Category
Article
ISSN
0361-8609

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✦ Synopsis

Intracytoplasmic inclusions were observed at light and electron microscopy in the cells of most of the hemopoietic series, including erythroblasts, in a case of multiple myeloma IgG kappa. The inclusions were of crystalline nature, surrounded by smooth membrane. An indirect immunoperoxidase method on thick sections confirmed their immunoglobulin G kappa nature. The fact that crystals were observed in various hemopoietic series suggests that, except for the plasma cells, their presence is more likely due to phagocytosis than to synthesis and, therefore, that they are not a clone marker.

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✍ R. GarcΓ­a-Sanz; M.I. GonzΓ‘lez-Fraile; G. Mateo; J.M. HernΓ‘ndez; M.C. LΓ³pez-Berge πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 158 KB

## Abstract Although multiple myeloma (MM) is predominantly a disease of the elderly, few studies have focused on the identification of prognostic factors in this group of patients. Four hundred twenty five MM patients >65 years were uniformly treated with chemotherapy (MP or VCMP/VBAD). Multivaria