## Abstract Highβresolution magnetic resonance imaging is emerging as a powerful tool for phenotyping mice in biologic studies of genetic expression, development, and disease progression. In several applications, notably random mutagenesis trials, large cohorts of mice must be examined for abnormal
Multiple-modulation-multiple-echo magnetic resonance
β Scribed by Eric E. Sigmund; Hyungjoon Cho; Yi-Qiao Song
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 974 KB
- Volume
- 30A
- Category
- Article
- ISSN
- 1546-6086
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β¦ Synopsis
Abstract
We describe several applications of a versatile pulse sequence family employing multiple spin echoes within one acquisition to accelerate multidimensional experiments. The core sequence, called multiple modulation multiple echo, measures the maximal set of spin echoes generated from a set of RF pulses with unequal time spacings. These echoes can be modulated individually to exhibit different encoding. As a result, one scan of the sequence determines a series of data points as a function of the specific encoding mechanism. The variety of realizations of this sequence includes single shot measurements of diffusion or flow in 1D, 2D, and singleβscan 2D sliceβselective imaging. The essential spin dynamics of such sequences is introduced and their applications are reviewed. Β© 2007 Wiley Periodicals, Inc. Concepts Magn Reson Part A 30A: 358β377, 2007.
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## Abstract We report a new type of SSFP imaging sequences for acquiring higherβorder echoes. Spins excited during a cycle have, in a sense, a phase memory such that they can be refocused several cycles down the line, and since the spins are pulsed under a steadyβstate condition, the resulting echo