โ Scribed by I. R. Epstein; E. Marder
No coin nor oath required. For personal study only.
We present a model for a conditional bursting neuron consisting of five conductances: Hodgkin-Hux-Icy type time-and voltage-dependent Na + and K + conductances, a calcium activated voltage-dependent K + conductance, a calcium-inhibited time-and voltagedependent Ca + + conductance, and a leakage C1-conductance. With an initial set of parameters (version S), the model shows a hyperpolarized steady-state membrane potential at which the neuron is silent. Increasing gNa and decreasing gel, where gi is the maximal conductance for species i, produces bursts of action potentials (Burster N). Alternatively, an increase in gc~ produces a different bursting state (Burster C). The two bursting states differ in the periods and amplitudes of their bursting pacemaker potentials. They show different steady-state I-V curves under simulated voltage-clamp conditions; in simulations that mimic a steady-state I-V curve taken under experimental conditions only Burster N shows a negative slope resistance region. Model C continues to burst in the presence of TTX, while bursting in Model N is suppressed in TTX. Hybrid models show a smooth transition between the two states.
๐ SIMILAR VOLUMES
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