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Multiple mechanisms of lymphocyte-mediated killing

✍ Scribed by John Ding-E Young; Chau-Ching Liu


Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
939 KB
Volume
9
Category
Article
ISSN
0167-5699

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Mechanisms of lymphocyte-mediated lysis
✍ Sanjay Joag; Arturo Zychlinsky; John Ding-E Young πŸ“‚ Article πŸ“… 1989 πŸ› John Wiley and Sons 🌐 English βš– 960 KB

Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells use multiple mechanisms to destroy their target cells. Pore formation resulting in osmotic lysis of the target is one mechanism; the pore-forming protein (perforin) responsible for this activity has been purified. Antigenically and functio