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Multiple mechanisms of cytochrome P450-catalyzed substrate hydroxylations

✍ Scribed by David C. Heimbrook; Stephen G. Sligar


Book ID
118315922
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
366 KB
Volume
99
Category
Article
ISSN
0006-291X

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Mechanisms of cytochrome P450 substrate
✍ F. Peter Guengerich πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 287 KB

## Abstract Cytochrome P450 (P450) enzymes catalyze a variety of oxidation and some reduction reactions, collectively involving thousands of substrates. A general chemical mechanism can be used to rationalize most of the oxidations and involves a perfenyl intermediate (FeO^3+^) and odd‐electron che