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Multiple mechanisms for doxorubicin cytotoxicity on glomerular epithelial cells ‘in vitro’

✍ Scribed by Ghiggeri, Gian Marco; Bertelli, Roberta; Ginevri, Fabrizio; Oleggini, Roberta; Altieri, Paola; Trivelli, Antonella; Gusmano, Rosanna

Book ID
122630622
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
651 KB
Volume
228
Category
Article
ISSN
0926-6917

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Methoxymorpholino doxorubicin (MMRDX) is an anthracycline analogue that is able to overcome tumor cell resistance to classical anthracyclines. Mechanisms for increased MMRDX cytotoxicity were analyzed in a small cell lung carcinoma cell line (GLC 4 ), its 300-fold doxorubicin-resistant and multidrug