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Multiple Hox/HOM-Class Homeoboxes in Platyhelminthes

โœ Scribed by Janet L. Bartels; Michael T. Murtha; Frank H. Ruddle

Book ID
102976262
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
811 KB
Volume
2
Category
Article
ISSN
1055-7903

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โœฆ Synopsis

The importance of the Hox/HOM class of homeobox genes in early anterior-posterior pattern formation and the conserved genomic organization of this gene family provides an interesting study in genome evolution. The Platyhelminthes (flatworms) are a basal metazoan group with a simple bilateral body plan. We used the polymerase chain reaction ((\mathrm{PCR})) to detect (\mathrm{Hox}) / HOM-class homeobox genes from species representing two classes of flatworms. Seven planarian and five trematode Hox HOM-class homeoboxes were found. The sequences of the genes are consistent with the pres. ence of one Hox/HOM-type cluster in the flatworms. Further analysis of this putative cluster may be expected to provide outgroup information for studying the evolution of the Hox/HOM clusters in the higher metazoa. 1993 Academic Press, Inc.

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