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Multiple epithelial and nonepithelial tumors in hereditary nonpolyposis colorectal cancer: characterization of germline and somatic mutations of the MSH2 gene and heterogeneity of replication error phenotypes

✍ Scribed by Rui-Len Huang; Chung-Faye Chao; Dah-Ching Ding; Cheng-Ping Yu; Cheng-Chang Chang; Hung-Chen Lai; Mu-Hsien Yu; Hang-Seng Liu; Tang-Yuan Chu


Book ID
113512404
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
353 KB
Volume
153
Category
Article
ISSN
0165-4608

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## Abstract A systematic search by Southern blot analysis in a cohort of 439 hereditary nonpolyposis colorectal cancer (HNPCC) families for genomic rearrangements in the main mismatch repair (MMR) genes, namely, __MSH2__, __MLH1__, __MSH6__, and __PMS2__, identified 48 genomic rearrangements causat