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Multiple endocrine neoplasias type 2A and thyroid medullary carcinoma: an interdisciplinary challenge

✍ Scribed by Frank-Martin Haecker; Daniel Oertli; Stefanie Gissler; Urs Zumsteg; Pierino Avoledo; Dietrich von Schweinitz


Publisher
Springer-Verlag
Year
2003
Tongue
English
Weight
137 KB
Volume
19
Category
Article
ISSN
0179-0358

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Communicated by Kenneth K. Kidd Gennline missense mutations within the coding region of the RET proto-oncogene have recently been described in patients with the dominantly inherited cancer syndromes, multiple endocrine neoplasia type 2a (MEN 2a) and familial medullary thyroid carcinoma (FMTC). To da

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Communicated by B w e A.J. Pondei Multiple endocrine neoplasia type 2 [MEN 21 is an autosomal dominant cancer syndrome with two subtypes, 2A and 2B. MEN 2A and medullary thyroid cancer [MTC] are caused by >25 different point mutations in exons 10, 11, and 13 of the RET proto-oncogene, whereas MEN 2B