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Multiple cross-reactive seif-ligands for Borrelia burgdorferi outer surface protein A (OspA)-specific HLA-DR4-restricted T Cells

✍ Scribed by Bert Maier; Marc Molinger; Andrew P. Cope; Lars Fugger; Jens Schneider-Mergener; Grete Sonderstrup; Achim Kramer; Thomas Kamradt

Book ID: 117637997
Publisher: Elsevier
Year: 1999
Tongue: English
Weight: 133 KB
Volume: 289
Category: Article
ISSN: 0934-8840
DOI: 10.1016/s0934-8840(99)80027-9

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Multiple cross-reactive self-ligands for Borrelia burgdorferi-specific HLA-DR4-restricted T cells

✍ Bert Maier; Marc Molinger; Andrew P. Cope; Lars Fugger; Jens Schneider-Mergener; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 352 KB

T cell recognition of self antigens is a key event in the pathogenesis of autoimmune diseases. To date, the initial events that trigger autoreactive T cells are unknown. The "molecular mimicry" hypothesis predicts that during an infection T cells that recognize both a microbial antigen and a related