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Multiple congenital anomalies associated with weekly low-dose methotrexate treatment of the mother

✍ Scribed by Lenore M. Buckley; Charles A. Bullaboy; Lawrence Leichtman; Mariella Marquez


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
337 KB
Volume
40
Category
Article
ISSN
0004-3591

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## BACKGROUND: Methotrexate is a proven teratogen and its use periconceptually is strongly advised against. Concerns about possible chromosomal effects in the offspring of women treated with this agent have been raised, but they have not been reported. In vivo and in vitro studies have supported t