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Multiorgan Transplacental and Neonatal Carcinogenicity of 3′-Azido-3′-deoxythymidine in Mice

✍ Scribed by Bhalchandra A. Diwan; Charles W. Riggs; Daniel Logsdon; Diana C. Haines; Ofelia A. Olivero; Jerry M. Rice; Stuart H. Yuspa; Miriam C. Poirier; Lucy M. Anderson


Book ID
112266982
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
187 KB
Volume
161
Category
Article
ISSN
0041-008X

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## Abstract A transplacental carcinogenicity study was conducted by exposing pregnant Swiss (CD‐1) mice to 0, 50, 100, 200, or 300 mg 3′‐azido‐3′‐deoxythymidine (AZT)/kg body weight (BW) daily for the duration of gestation (18–19 days) [National Toxicology Program,2006]. The incidence of alveolar/b