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Multinuclear Non-Heme Iron Complexes for Double-Strand DNA Cleavage

✍ Scribed by Rik P. Megens; Tieme A. van den Berg; A. Dowine de Bruijn; Ben L. Feringa; Gerard Roelfes


Book ID
101836639
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
430 KB
Volume
15
Category
Article
ISSN
0947-6539

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✍ Michael J. McLean; Ahsana Dar; Michael J. Waring 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 861 KB

The sequence specificity of bleomycin A5 and of its light-activated cobalt complex were compared by examining the relative cleavage of each strand of two DNA fragments by either species. Significant differences between the two metallobleomycins were observed. The iron-bleomycin (Fe-BLM) complex clea