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Multinuclear NMR spectroscopy and antiproliferative activity in vitro of platinum(II) and palladium(II) complexes with 6-mercaptopurine

✍ Scribed by Iwona Łakomska; Leszek Pazderski; Jerzy Sitkowski; Lech Kozerski; Marzena Pełczyńska; Anna Nasulewicz; Adam Opolski; Edward Szłyk

Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
149 KB
Volume
707
Category
Article
ISSN
0022-2860

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✦ Synopsis

A series of Pd(II) and Pt(II) complexes with 6-mercaptopurine (6-Hmp) of formulae 3), Pt(6-mp)(dmso)Cl (4) was synthesized and studied by IR, far-IR, 1 H, 13 C, 15 N NMR. ( 1) has an ionic character and consists of distinct [Pd(6-Hmp) 2 ] 2C cations and uncoordinated Cl K anions, whereas (2,3) are neutral species with central atoms bis-chelated by the deprotonated 6-mp K ligands. NMR studies suggest that S and N(7) are the complexation sites, while far-IR spectra indicate the squareplanar geometry of Pd(II) or Pt(II). In (4) the Pt(II) atom is coordinated by one chelating 6-mp K anion, S-bonded dmso molecule and a terminal chloride. The antiproliferative activity in vitro of (2-4) was tested against human leukaemia HL-60 cells, being exhibited for (2) at the level ca. six times lower than in case of cisplatin.

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