Multinuclear 1D and 2D NMR Investigations on the Interaction between the Pyrimidic Nucleotides 5′-CMP, 5′-dCMP, and 5′-UMP and Diethyltin Dichloride in Aqueous Medium

✍ Scribed by Laurent Ghys; Monique Biesemans; Marcel Gielen; Achilleas Garoufis; Nick Hadjiliadis; Rudolph Willem; José C. Martins

• Book ID: 101274268
• Publisher: John Wiley and Sons
• Year: 2000
• Tongue: English
• Weight: 336 KB
• Volume: 2000
• Category: Article
• ISSN: 1434-1948
• DOI: 10.1002/(sici)1099-0682(200003)2000:3<513::aid-ejic513>3.0.co;2-m

✦ Synopsis

The interactions between diethyltin dichloride and 5'-CMP, 5'-dCMP, and 5'-UMP in aqueous solution were investigated by multinuclear 1D and 2D NMR techniques including 119 Sn, 15 N and 31 P nuclei. These studies were combined with electrospray mass spectrometry, infrared spectroscopy, solid state 13 C, 31 P and 117 Sn CP-MAS NMR, and elemental analysis. As demonstrated by 31 P-1 H HOESY spectroscopy, the diethyltin moiety interacts with the phosphate group of the pyrimidic mononucleotides in the pH range 0.5-3.5. Compound 8 (X = Cl), the solid isolated in this pH range from 5'-CMP, contains two tin atoms bridged by one oxygen and one chlorine atom,