Multimodality therapy of an acquired factor V inhibitor

✍ Scribed by Fu, Yang-Xin; Kaufman, Richard; Rudolph, Amy E.; Collum, Steven E.; Blinder, Morey A.

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 357 KB
• Volume: 51
• Category: Article
• ISSN: 0361-8609
• DOI: 10.1002/(sici)1096-8652(199604)51:4<315::aid-ajh11>3.0.co;2-d

✦ Synopsis

Acquired inhibitors of factor V are rare causes of clinlcai bleeding, whose severity ranges from mild to iife-threatening. Optimal treatment of patients with factor V inhibitors is uncertain. We report on our successful treatment approach in a patient with spontaneous, life-threatening intracraniai bleeding caused by a factor V Inhibitor. The patient deteriorated after Initial treatment with fresh-frozen plasma and platelet transfusions. He was subsequently treated with a combination of plasma exchange and chemotherapy, which led to complete recovery. Our experience suggests that plasma exchange may be iifesaving in cases of severe bleedlng caused by factor V inhibitors. The use of plasmapheresis in conjunction wlth chemotherapy Is an efflcacious and well-tolerated treatment and should be considered in patients with factor V inhibitors.