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Multimodality bronchoscopic imaging of recurrent respiratory papillomatosis

✍ Scribed by Henri G. Colt; Septimiu D. Murgu; Bockhyun Jung; Yeh-Chan Ahn; Matt Brenner

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
284 KB
Volume
120
Category
Article
ISSN
0023-852X

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✦ Synopsis

Abstract

Objectives/Hypothesis.

Recurrent respiratory papillomatosis (RRP) of the central airways requires removal to potentially reduce recurrence and risk for malignant transformation. Analogous to the principles of treatment for early lung cancer, a precise determination of the extent of cartilage invasion could help guide therapeutic decisions and monitor response to treatment. The purpose of this study was to determine whether a bronchoscopy platform comprised of white light bronchoscopy (WLB), endobronchial ultrasound (EBUS), and optical coherence tomography (OCT) could identify layered microstructure of RRP and underlying cartilage.

Study Design.

Case study.

Methods.

A bronchoscopy platform consisting of commercially available WLB, EBUS using a 7.5 MHz convex probe (BF‐UC 160F; Olympus Optical Co. Ltd, Tokyo, Japan), and a time‐domain OCT with front imaging and inside actuation (Niris Imaging System; Imalux Corp., Cleveland, OH) was used in a patient with tracheal stenosis from RRP. Findings are compared with results of histology and the characteristics of imaging modalities are discussed.

Results.

WLB revealed tracheal pedunculated lesions. EBUS showed a 1‐cm hypoechogenic density corresponding to the papilloma, visualized above a hyperechogenic density corresponding to tracheal cartilage. There was no sonographic evidence of cartilage disruption or adjacent lymphadenopathy. OCT revealed a layer of heterogeneous light backscattering suggesting the mucosal papilloma, and a layer of high‐degree scattering, corresponding to the central fibrovascular core noted on histology.

Conclusions.

Layered microstructures of RRP and underlying airway cartilage can be identified using a combination of acoustic and optical bronchoscopic imaging modalities with different resolution and depth of penetration characteristics. Laryngoscope, 2010

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