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Multimodal approach in the therapy of stage III female breast cancers

✍ Scribed by V. Shanta; S. Krishnamurthi; D. V. L. N. Sastry; Ranjini Menon

Publisher: John Wiley and Sons
Year: 1985
Tongue: English
Weight: 506 KB
Volume: 28
Category: Article
ISSN: 0022-4790
DOI: 10.1002/jso.2930280214

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✦ Synopsis

One thousand thirty-seven female breast cancers were treated at the Cancer Institute (WIA), Madras, between 1965 and 1978. Five hundred twenty-one of them (ie, just over 50%) were in stage 111, with extensive local disease, unsuitable for surgery ab initio. Four hundred twelve of them (group A) received radiation therapy (RT) initially and 109 (group B) a combination of radiation and chemotherapy (CT). In 68% of the former and 77% of the latter the tumours became resectable after this preliminary treatment. Radical mastectomy in group A and Patey's mastectomy in group B were performed. The material in these two groups was similar. The five-year survival NED in group A was 45 % , and in group B 64.61 % . Adequate surgery following RT and CT seemed essential to improve survival. The impact of added chemotherapy (CT) was mainly felt in the node-positive cases.

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