Multilobated non-hodgkin's lymphoma. A clinicopathologic entity

✍ Scribed by Joop Van Baarlen; Henk-Jan Schuurman; Jan A. M. Van Unnik

• Publisher: John Wiley and Sons
• Year: 1988
• Tongue: English
• Weight: 561 KB
• Volume: 61
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19880401)61:7<1371::aid-cncr2820610716>3.0.co;2-g

✦ Synopsis

Multilobated non-Hodgkin's lymphomas (NHL) have recently been recognized as an NHL variant. During a period of 10 years we observed 30 individuals with NHL in which more than 30% of the malignant cells had a characteristic multilobation. The immunologic phenotype was determined in 14 of these cases. One was of T-cell lineage, and the others exhibited B-lymphoid markers. Sixty-eight percent of the patients presented with extranodal localizations. In the clinical follow-up a complete remission was observed in 78% of patients with a mean duration of 37 months (range, 5 to 120 months). The actuarial survival after 5 years was 45%. From these data we conclude that multilobated NHL are comparable to diffuse, large cleaved-cell NHL of an intermediate grade malignancy according to the Working Formulation or are comparable to the diffuse centrocytic-centroblastic NHL according to the Kiel classification. The neoplastic cells are to be considered as variants of follicle center cells, but the clinicopathologic correlation indicates that multilobated NHL represent a distinct nosologic entity.