Nanocrystal-based organic-inorganic functional hybrid materials with novel, exceptional properties have been explored in recent years because of their potential applications in nanobiotechnology. [1] Viral assembly of inorganic nanoparticles, [2a] and their polypeptide [2b,c] and ligand-receptor-mediated organization [2d] and protein-templated synthesis [2e] are a few examples in this direction. Of utmost interest in this context are lipid molecules because of their unique ability to form a variety of self-organized, supramolecular structures. [3] Although planar and vesicular lipid membranes have been used to compartmentalize and to synthesize nanocrystals in a confined volume, [4] the enormous possibilities of lipid-based, biocompatible nano/microstructures in nanobiotechnology have still to be fully exploited. For example, native and artificial vesicles offer novel possibilities for investigating (bio)chemical reactions and cellular signal transduction processes at the nanometer and attoliter scales. [5] Furthermore, the interaction between specially designed lipid vesicles and mammalian cells (adsorption, fusion, endocytosis) [6a] has been used to deliver DNA and RNA into cells, and has high potential for smart diagnostics, controlled drug delivery, and gene transfer. [4a, 6] Inorganic nanoparticles could offer new ways to image native and artificial vesicles and control (bio)chemical reactions therein, if it is possible to selectively position the particles on or within the vesicles.