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Multifactorial nature of high frequency of mitochondrial DNA mutations in somatic mammalian cells

✍ Scribed by I. N. Todorov; G. I. Todorov

Book ID
110155227
Publisher
Springer
Year
2009
Tongue
English
Weight
262 KB
Volume
74
Category
Article
ISSN
0006-2979

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## Abstract Recent studies of various cancers, such as those of the breast, head and neck, bladder and lung, reported that 46–64% of somatic mutations in the D‐loop region of mitochondrial DNA (mtDNA) are observed. However, in esophageal cancer, only a low rate (5%) of somatic mutations has so far