Multifaceted activity of HIV Vpr/Vpx proteins: the current view of their virological functions
✍ Scribed by Mikako Fujita; Masami Otsuka; Masako Nomaguchi; Akio Adachi
- Book ID
- 104590696
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 213 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1052-9276
- DOI
- 10.1002/rmv.636
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✦ Synopsis
Abstract
Primate immunodeficiency viruses encode viral proteins that are uniquely auxiliary to their growth in host cells. Of these accessory proteins, those designated Vpr and Vpx are least well understood with respect to their functions in the viral replication cycle. Moreover, their assigned roles based on the results in published studies remain controversial. This review summarises current knowledge on human immunodeficiency virus (HIV) Vpr/Vpx proteins, and discusses their functional activities during the viral life cycle in macrophages and T lymphocytes, the two major target cells of HIV infection. Copyright © 2010 John Wiley & Sons, Ltd.