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Multidrug resistance is more than MDR1 activity

✍ Scribed by H.D. Preisler

Book ID
113240077
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
307 KB
Volume
19
Category
Article
ISSN
0145-2126

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The most consistantly reported alteration of multidrug-resistant carcinoma cells is the overexpression of a membrane glycoprotein, termed P-glycoprotein. In this study we examined whether the strong intrinsic chemotherapy resistance of glial tumors might be related to the expression of the MDR1 gene