Multidrug resistance and the role of P-glycoprotein knockout mice
β Scribed by A.H Schinkel; C.A.A.M Mol; E Wagenaar; L van Deemter; J.J.M Smit; P Borst
- Book ID
- 116166300
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 510 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0959-8049
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Clinicians have long observed that treatment with one anticancer drug can confer resistance to that drug and to other anticancer drugs with different chemical structures and mechanisms of action. This is the multidrug resistance (MDR) phenomenon, which frequently occurs in the absence of previous ch
acetate; OAG, I-oleoyl 2-acetylglycerol; P(BtO)" phorhol 12, 13-dihutyrate; NASV, N-(p-azido [3-'25 Ijsalicyl)-N' -(J3-aminoethyl)vindesine; NABV, N-(p-azido-[3 ,5-3 Hjbenzoyl)-N' -(13aminoethyl)vindesine; OM, double minutes; HSR, homogeneously staining region.