Multicomponent solution phase synthesis of dehydroamino acid derivatives based on the Passerini reaction

✍ Scribed by Sang Woong Kim; Shawn M. Bauer; Robert W. Armstrong

• Book ID: 104259867
• Publisher: Elsevier Science
• Year: 1998
• Tongue: French
• Weight: 191 KB
• Volume: 39
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(98)01522-6

✦ Synopsis

We have synthesized a library of dehydroamino acid derivatives using a Passerini three component condensation reaction. A number of structurally diverse inputs were used, thus demonstrating a large tolerance of functionality for the key transformation.