Multichannel diode array UV—visible spectrophotometer as detector in screening for unknown butoprozine metabolites in dog bile by high-performance liquid chromatography

High-performance liquid chromatography w

High-performance liquid chromatography with continuous gradient elution in screening for unknown metabolites of butoprozine directly in dog bile

✍ Overzet, F. ;Drenth, B. F. H. ;de Zeeuw, R. A. 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB

## Abstract This paper describes the screening for metabolites of butoprozine, a new anti‐anginal drug, in dog bile by means of reverse‐phase HPLC. Although it does involve a simple clean‐up step to remove a substantial amount of endogenous bile compounds, this screening method nevertheless avoids