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Multicentric reticulohistiocytosis in a child

✍ Scribed by S Havill; M Duffill; M Rademaker

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
95 KB
Volume
40
Category
Article
ISSN
0004-8380

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✦ Synopsis

A case of multicentric reticulohistiocytosis in an 8‐year‐old girl, which is a diagnosis rarely seen in children, is presented. Multicentric reticulohistiocytosis is a disorder of unknown aetiology, predominantly affecting the joints, skin and mucosa. Joint symptoms, but not cutaneous lesions, have improved with treatment with methotrexate.

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Multicentric reticulohistiocytosis (MRH) is a rare systemic disease of unknown etiology characterized histologically by widespread infiltrations of multinucleate giant cells and lipid-laden histiocytes. Rapidly destructive polyarthritis and nodular skin lesions are the most significant manifestation