Multicentric reticulohistiocytosis associated with ovarian cancer
β Scribed by Takayuki Kishikawa; Taichiro Miyashita; Emiko Fujiwara; Osamu Shimomura; Ichiro Yasuhi; Daisuke Niino; Masahiro Ito; Misato Amenomori; Hideaki Osumimoto; Mitsuhiko Osumi; Katsumi Eguchi; Kiyoshi Migita
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 453 KB
- Volume
- 17
- Category
- Article
- ISSN
- 1439-7595
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Multicentric reticulohistiocytosis (MRH) is a rare systemic disease of unknown etiology characterized histologically by widespread infiltrations of multinucleate giant cells and lipid-laden histiocytes. Rapidly destructive polyarthritis and nodular skin lesions are the most significant manifestation
## Abstract The development of cancer is a multistep process that is characterized by the accumulation of genetic alterations in cells and changed cellular interactions with the surrounding healthy tissues. The human immune system is believed to be intrinsically involved in this process. The correl