Multicenter validation of the magnetic resonance t2* technique for segmental and global quantification of myocardial iron

✍ Scribed by Anna Ramazzotti; Alessia Pepe; Vincenzo Positano; Giuseppe Rossi; Daniele De Marchi; Maria Gabriella Brizi; Antongiulio Luciani; Massimo Midiri; Giuseppina Sallustio; Gianluca Valeri; Vincenzo Caruso; Michele Centra; Paolo Cianciulli; Vincenzo De Sanctis; Aurelio Maggio; Massimo Lombardi

• Publisher: John Wiley and Sons
• Year: 2009
• Tongue: English
• Weight: 504 KB
• Volume: 30
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.21781

✦ Synopsis

Abstract

Purpose

To assess the transferability of the magnetic resonance imaging (MRI) multislice multiecho T2* technique for global and segmental measurement of iron overload in thalassemia patients.

Materials and Methods

Multiecho T2* sequences were installed on six MRI scanners. Five healthy subjects (n = 30) were scanned at each site; five thalassemia major (TM) patients were scanned at the reference site and were rescanned locally (n = 25) within 1 month. T2* images were analyzed using previously validated software.

Results

T2* values of healthy subjects showed intersite homogeneity. On TM patients, for global heart T2* values the correlation coefficient was 0.97, coefficients of variation (CoV~s~) ranged from 0.04–0.12, and intraclass coefficients (ICC~s~) ranged from 0.94–0.99. The mean CoV and ICC for segmental T2* distribution were 0.198 and 88, respectively.

Conclusion

The multislice multiecho T2* technique is transferable among scanners with good reproducibility. J. Magn. Reson. Imaging 2009;30:62–68. © 2009 Wiley‐Liss, Inc.