Multi-ribozyme Targeting of Human α-Globin Gene Expression
✍ Scribed by Tong-Jian Shen; Pranvera Ikonomi; Reginald Smith; Constance Tom Noguchi; Chien Ho1
- Book ID
- 115590004
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 290 KB
- Volume
- 25
- Category
- Article
- ISSN
- 1079-9796
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HS-26, the mouse homologue of HS-40, is the major regulatory element of the mouse ␣-globin gene locus. Like HS-40, HS-26 is located within an intron of a house-keeping gene; comparison of the nucleotide sequences of HS-26 and HS-40 reveals conservation of the sequences and positions of several DNA b
The high level expression of the human alpha-globin genes in erythroid tissue appears to require a set of DNaseI hypersensitive sites located upstream of the human alpha-globin gene cluster. These sequences, termed the locus control region (LCR), include two erythroid specific and a number of less r