We have developed a novel, fully automatic method for aligning the three-dimensional structures of two proteins. The basic approach is to first align the proteins' secondary structure elements and then extend the alignment to include any equivalent residues found in loops or turns. The initial secon
Multi-objective highway alignment optimization using a genetic algorithm
✍ Scribed by Avijit Maji; Manoj K. Jha
- Publisher
- Institute for Transportation Inc.
- Year
- 2009
- Tongue
- English
- Weight
- 167 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0197-6729
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
The available highway alignment optimization algorithms use the total cost as the objective function. This is a single objective optimization process. In this process, travel‐time, vehicle operation accident earthwork land acquisition and pavement construction costs are the basic components of the total cost. This single objective highway alignment optimization process has limited capability in handling the cost components separately. Moreover, this process cannot yield a set of alternative solutions from a single run. This paper presents a multi‐objective approach to overcome these shortcomings. Some of the cost components of highway alignments are conflicting in nature. Minimizing some of them will yield a straighter alignment; whereas, minimizing others would make the alignment circuitous. Therefore, the goal of the multiobjective optimization approach is to handle the trade‐off amongst the highway alignment design objectives and present a set of near optimal solutions. The highway alignment objectives, i.e., cost functions, are not continuous in nature. Hence, a special genetic algorithm based multi‐objective optimization algorithm is suggested The proposed methodology is demonstrated via a case study at the end.
📜 SIMILAR VOLUMES
## Abstract Bulk of the penicillin produced is used as raw material for semi‐synthetic penicillin (such as amoxicillin and ampicillin) and semi‐synthetic cephalosporins (such as cephalexin and cefadroxil). In the present paper, an industrial penicillin V bioreactor train is optimized for multiple o
A multiobjective optimization technique has been developed for free radical bulk polymerization reactors using genetic algorithm. The polymerization of methyl methacrylate in a batch reactor has been studied as an example. The two objective functions which are minimized are the total reaction time a
For many optimum design problems, the objecti®e function is the result of a complex numerical code and may not be differentiable and explicit. The first aim is to propose a way of sol®ing such complexity on an example problem. A no®el and global strategy in®ol®ing artificial neural networks and a ge