Multi-level regulation of Thy-1 antigen expression in mouse T lymphomas
✍ Scribed by Nicolas J. Fasel; Nicole Déglon
- Book ID
- 104656744
- Publisher
- Springer-Verlag
- Year
- 1992
- Tongue
- English
- Weight
- 695 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0093-7711
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Most cells in the normal adult mouse thymus express Thy-1 glycoprotein but do not express Pgp-1 glycoprotein. In contrast, cells of the mouse B-cell lineage are Thy-1 negative and Pgp-1 positive. Somatic cell hybrids between pseudodiploid Thy-1+, Pgp-1- T-cell lymphomas and pseudotetraploid Thy-1-,
Mouse malignant T-lymphoma CS-21 cells can survive and proliferate in vitro when co-cultured with CA-I 2 stromal cells isolated from lymph nodes, but CS-2 I cells undergo apoptotic cell death with DNA fragmentation when cultured alone. We immunized rats with CS-2 I cells and raised monoclonal antibo