Mucus as a barrier to the permeability of hydrophilic and lipophilic compounds in the absence and presence of sodium taurocholate micellar systems using cell culture models

Progress and limitations in the use of i

Progress and limitations in the use of in vitro cell cultures to serve as a permeability screen for the blood-brain barrier

✍ Mark Gumbleton; Kenneth L. Audus 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 200 KB 👁 1 views

A relatively simple, widely applicable, and robust in vitro method of predicting blood-brain barrier (BBB) permeability to central nervous system-acting drugs is an increasing need. A cell-based model offers the potential to account for transcellular and paracellular drug diffusional processes, meta